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Updated: May 3, 2026

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超分子フィラメントのキラリティは,アミロイド繊維の主要な形態学的差異の根本的な原因ですか?

Dmitry Kurouski1, Xuefang Lu, Ludmila Popova

  • 1Department of Chemistry, University at Albany, State University of New York , 1400 Washington Avenue, Albany, New York 12222, United States.

Journal of the American Chemical Society
|February 4, 2014
PubMed
まとめ

振動的円形二重化 (VCD) は,アミロイド線維のキラリティが形態論を決定することを明らかにします. この発見は,繊維構造と細胞毒性を関連付け,キラリティがアミロイド疾患の鍵であることを示唆しています.

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