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Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
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中枢神経系の損傷部位への移植後の神経幹細胞の拡散

Mark H Tuszynski1, Yaozhi Wang2, Lori Graham2

  • 1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Veterans Administration Medical Center, San Diego, CA 92161, USA.

Cell
|February 4, 2014
PubMed
まとめ

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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