血管内皮のプロゲステロン受容体は,生理学的子宮の浸透性を誘発する
Lauren M Goddard1, Thomas J Murphy2, Tönis Org1
1Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell
|February 4, 2014
まとめ
プロゲステロン受容体 (PR) は,VEGFから独立して,胚の埋め込みのための生理学的血管透過性を制御します. PRは,生殖の成功に不可欠なNR4A1遺伝子を介して血管の漏れを調節します.
科学分野:
- 生殖生物学 生殖生物学
- 血管生物学 血管生物学とは
- エンドクリノロジー エンドクリノロジー
背景:
- 血管の浸透性は炎症とVEGF.のような要因に関連しています.
- 生理学的血管透過性は,胚の移植に不可欠である.
研究 の 目的:
- 胚の植入時に生理学的血管透過性を調節するプロゲステロン受容体 (PR) の役割を調査する.
- PRが血管透過性を制御する分子メカニズムを特定する.
主な方法:
- 全球性および内皮特異性PR消去マウスモデルを使用した.
- ゲノム全体の転写プロファイリングと内皮細胞におけるChIP配列決定を行いました.
- PR媒介による血管透過性におけるNR4A1 (Nur77/TR3) の役割を調査した.
主要な成果:
- プロゲステロン受容体 (PR) は,VEGFから独立して,移植のための子宮血管の透過性を直接制御します.
- 内皮細胞におけるPRの消去は,生理学的血管透過性を阻害し,誤った発現は子宮外漏れを引き起こします.
- PRはNR4A1依存の転写プログラムを誘導し,交差点タンパク質を抑制し,血管バリア機能を調節します.
結論:
- プロゲステロン受容体 (PR) は,胚の植え付けに不可欠な生理学的血管浸透性の主要な調節体です.
- PR-NR4A1経路は,生殖中の静脈特異的血管壁の調節を媒介する.
- この経路をターゲットにすると,生殖器系および血管疾患の洞察が得られます.
さらに関連する動画
05:30Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
Published on: November 8, 2024
1.0K
05:13Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
Published on: June 21, 2024
1.9K
関連する概念動画
01:20Proliferative Phase
1.9K
The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
1.9K
01:27Ovarian Cycle
5.4K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
5.4K
01:25Physiological Barriers
5.0K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.0K
01:07Teratogenicity
4.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
01:22Hormonal Regulation of the Menstrual Cycle
2.4K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
2.4K
01:18Menses Phase
1.5K
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
1.5K