保護性腫瘍の微小環境を抗体介護療法に敏感にする
Christian P Pallasch1, Ilya Leskov2, Christian J Braun2
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Internal Medicine, Center of Integrated Oncology, University of Cologne, Cologne 50931, Germany.
Cell
|February 4, 2014
まとめ
化学療法は,腫瘍の微小環境を変更することによって,抗体療法を強化することができます. サイクロフォスファミドは,マクロファージの活動を促進するサイトカインを誘導し,免疫系が白血病細胞を排除する能力を向上させます.
科学分野:
- 免疫学 免疫学とは
- 腫瘍学 腫瘍学
- 薬理学 薬理学とは
背景:
- 治療に耐性のある微小環境は,拡散した癌の治療に重大な課題をもたらします.
- 抗体ベースの治療は,腫瘍の微環境媒介による耐性のために無効である可能性があります.
研究 の 目的:
- B細胞白血病における抗体療法に対する耐性のメカニズムを調査する.
- 腫瘍の微小環境を調節することによって,治療抵抗を克服するための戦略を特定する.
主な方法:
- 治療抵抗性B細胞白血病の人間化されたモデルを使用した.
- 治療用抗体とサイクロフォスファミドの組み合わせを投与した.
- 骨髄腫瘍の微環境とマクロファージの活動における変化を分析した.
主要な成果:
- 白血病細胞が骨髄に浸透すると,抵抗性の高い微環境が形成され,抗体媒介によるクリアランスを阻害する.
- サイクロフォスファミドは,腫瘍細胞における急性分泌活性化フェノタイプ (ASAP) を誘導し,サイトカイン (CCL4,IL8,VEGF,TNFα) を放出する.
- 放出されたこれらのサイトカインは,マクロファージの浸透を促進し,骨髄におけるファゴサイト活動を強化します.
結論:
- 化学免疫療法,特にサイクロフォスファミドと治療用抗体との組み合わせは,耐性を克服することができます.
- ストレス関連のサイトカインを誘発することで,がん細胞の除去のために生まれながらの免疫系を効果的に関与させることができます.
- この戦略は,腫瘍の微小環境を変化させることで,標的治療を強化するための強力なアプローチを提供します.
さらに関連する動画
08:32Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
10.5K
10:13A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
Published on: November 7, 2015
11.7K
関連する概念動画
01:27Protecting Self-Esteem
238
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
238
02:17The Tumor Microenvironment
7.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.9K
01:10Antibody Structure
65.8K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.8K
02:31Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
01:16Zones of Protection
818
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
818
01:23Radial System Protection
448
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
448