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熟練した到達は,V2aの自脊椎の内部コピー回路に依存しています
Eiman Azim1, Juan Jiang2, Bror Alstermark2
1Howard Hughes Medical Institute, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Nature
|February 4, 2014
まとめ
頸椎性脊髄神経 (PNs) は,前肢に精密に到達するために不可欠な運動コマンドの内部コピーを提供します. これらのV2a PNsを消去または活性化すると,目標指向の達成が妨げられ,モーター制御におけるその役割が強調されます.
科学分野:
- 神経科学は神経科学である.
- モーター・コントロール・コントロール
- 脊髄生理学 脊髄生理学
背景:
- 熟練した前肢の動きの精度は,フィードバック訂正のための運動コマンドの内部コピーに依存すると考えられています.
- これらの内部複製回路の機能的役割,特に脊髄内での役割は,まだ十分に理解されていません.
研究 の 目的:
- 頸椎性脊髄ニューロン (PNs) が,目標指向の前肢伸長における内部複製経路としての役割を調査する.
- PNSのサブ集団であるV2aインターニューロンが,この運動制御メカニズムに関与しているかどうかを判断する.
主な方法:
- マウスの頸部V2a内ニューロンの標的切除.
- PN内部複製経路の光遺伝的活性化.
- タスクに到達する際の前肢運動動力学の分析.
主要な成果:
- V2a PNsの切除は,特に,手の届く行動が低下し,他の前肢の動きは無傷のままである.
- PN内部複製経路の光遺伝的活性化は,小脳フィードバックループを通じてモーターニューロン活動を調節することによって,運動力学に到達することを妨げました.
- これらの発見は,V2a PNsは,高速なモーター出力の更新のための内部コピーパスの不可欠な部分であることを示しています.
結論:
- 子宮頸部V2a PNsは,正確な,目標指向の前肢伸縮のための重要な内部コピー経路として機能します.
- この経路は,小脳フィードバックループとモーターニューロン活動に影響することによって,速やかに運動出力を更新します.
- この研究では,V2a PNsが動作実行のリアルタイムの調節に関与している.
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