生まれながらのリンパ性細胞へのコミットされた前駆体です
Michael G Constantinides1, Benjamin D McDonald1, Philip A Verhoef1
1Committee on Immunology, Department of Pathology, The Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.
Nature
|February 11, 2014
まとめ
研究者らは,転写因子PLZFによって定義される新しい前駆細胞,先天性リンパ性細胞前駆細胞 (ILCP) を発見した. この発見は,先天性リンパ性細胞 (ILC),自然キラー (NK) 細胞,およびリンパ性組織誘導体 (LTis) の間の発達的関係を明確にします.
科学分野:
- 免疫学 免疫学とは
- 発達生物学 発達生物学とは
- 細胞生物学 細胞生物学
背景:
- 生まれながらのリンパ性細胞 (ILC) は免疫と組織修復に不可欠ですが,その発達の起源と他の生まれながらのリンパ細胞との関係は不明です.
- 現在,ILCを1,2,3グループに分類する方法は,発達の経路ではなく,サイトカインプロファイルに基づいています.
- ILCs,自然キラー (NK) 細胞,リンパ性組織誘発体 (LTis) の間の類似性は,共通の発達の起源を示唆しています.
研究 の 目的:
- 生まれながらのリンパ性細胞の新型前駆者を特定し,特徴づけること.
- ILC,NK細胞,LT細胞の発達経路と系統関係を明らかにする.
- 転写因子PLZFが先天性リンパ球の分化に果たす役割を決定する.
主な方法:
- ネズミの胎児肝臓と成人の骨髄における系統追跡と移植の研究.
- 高レベルのPLZFを発現する新しいリンパ性前駆体集団の特徴化.
- PLZFの削除後のILCサブセット開発の分析.
主要な成果:
- ネズミの免疫器官における新しい前駆体集団,PLZF (高) 細胞の特定.
- PLZF (高) 細胞は,マルチポテンシャルの可能性を示し,ILC1,ILC2,およびILC3のサブセットを生み出しました.
- PLZFの削除は,ILCサブセットの開発に大きく影響し,PLZFの重要な役割を確認しました.
- これらの前駆体は,古典的なLTiおよびNK細胞とは異なるが,NK1.1(+) DX5(-) "NKのような"細胞のサブセットを含んでいた.
結論:
- ILC,NK,およびLTi細胞間の新しい系統関係の確立.
- ILCsの共通の前駆体である先天性リンパ性細胞前駆体 (ILCP) の特定.
- 転写因子PLZFが先天性リンパ球の分化において広く決定的な役割を果たしていることを確認した.
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