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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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ダイアステロセレクティブPtは,ポリエンのサイクロアイソメリゼーションをポリサイクルに触媒化します

Michael J Geier1, Michel R Gagné

  • 1Caudill Laboratories, Department of Chemistry, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.

Journal of the American Chemical Society
|February 13, 2014
PubMed
まとめ

研究者たちは,単純なアルケーンから複雑なポリサイクリック分子を作り出すための特別なリガンドを使用して,新しいプラチナ触媒反応を開発しました. この方法は,価値ある有機化合物を合成するためのダイアステレオ選択的経路を提供します.

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Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
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