コミュニティで得られた細菌血症後の心筋梗塞と脳卒中のリスク:20年間の集団ベースのコホート研究
Michael Dalager-Pedersen1, Mette Søgaard, Henrik Carl Schønheyder
1Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark (M.D.-P., H.N.); Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark (M.D.-P., M.S., R.W.T.); and Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark (H.C.S.).
Circulation
|February 14, 2014
まとめ
コミュニティで得られた細菌血症は,短期的に心筋梗塞と脳卒中のリスクを大幅に高めます. この心血管疾患のリスクの増加は,感染後30日以内に最も顕著です.
科学分野:
- 心臓病学 心臓病学
- 感染症 感染症は感染症です.
- エピデミオロジー エピデミオロジー
背景:
- 感染症は,急性心血管疾患の発生を早める可能性があります.
- コミュニティで発症した細菌血症の後に発症する心筋梗塞や脳卒中のリスクは,依然としてほとんど不明です.
研究 の 目的:
- コミュニティで発症した細菌血症の1年以内に急性心筋梗塞および不全性脳卒中のリスクを評価する.
主な方法:
- 北デンマークの集団ベースのコホート研究で,細菌血症の入院患者4389人が参加しました.
- バクテリーミアの患者と一般人群と入院した非バクテリーミアの対照群とのマッチング.
- 心筋梗塞や脳卒中の発生を365日間の医療データベースで確認する.
- 相対的なリスクと危険比率を決定するための多変量回帰分析.
主要な成果:
- 細菌血症の30日以内に心筋梗塞または脳卒中のリスクが大幅に増加することが観察されました (調整された相対リスク20.86対集団コントロール).
- 人口対照群と比較して,リスクのわずかな増加は31日から180日 (調整されたハザード比1.64) に続いた.
- 6ヶ月後には,対照群に関係なく,有意な心血管リスクの違いは認められなかった.
結論:
- コミュニティで発症した細菌血症は,短期的に心筋梗塞や脳卒中のリスクの増加と関連しています.
- この発見は,バクテリア血症後の患者の心血管健康のモニタリングの重要性を強調しています.
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