アミロイド形成の基礎となる分子イベントにおける安定したα-シヌクレインオリゴマーの役割

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A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
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Nikolai Lorenzen1, Søren Bang Nielsen, Alexander K Buell

  • 1Department of Molecular Biology, Center for Insoluble Protein Structures (inSPIN) and §Department of Chemistry, Interdisciplinary Nanoscience Center (iNANO), Aarhus University , Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.

Journal of the American Chemical Society
|February 18, 2014
PubMed
まとめ

研究者らは,パーキンソン病の病原化に関与する2つの異なるアルファ-シヌクレインオリゴーマーを特徴付けました. これらのオリゴマーは,膀を浸透させることができるが,アミロイド繊維の形成を阻害し,明確な集積経路を示唆する.

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