Jove
Visualize
お問い合わせ

関連する概念動画

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.1K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.1K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

22.9K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.9K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.8K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

3.4K
3.4K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

1.9K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
1.9K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.5K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

COVID-19 symptom severity and duration among outpatients, July 2021-May 2023: The PROTECT observational study.

PloS one·2025
Same author

Seraph 100 Hemoperfusion for Management of Severe COVID-19: Assessment of Serum and Plasma Analytes Pre- and Post-Filtration.

Blood purification·2024
Same author

Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Retrospective Analysis of Blood Biomarkers of Neurological Injury in Human Cases of Viral Infection and Bacterial Sepsis.

The Journal of infectious diseases·2024
Same author

Individual variation in the emergence of anterior-to-posterior neural fates from human pluripotent stem cells.

Stem cell reports·2024
Same author

Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae.

The Journal of infectious diseases·2024
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
関連記事をすべて見る
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する実験動画

Updated: May 3, 2026

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
09:51

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

Published on: April 10, 2026

90

プラリポテンシーへのスピードアップ

Josh G Chenoweth1, Ronald D McKay1

  • 1Lieber Institute for Brain Development, 855 N. Wolfe Street, Baltimore, MD 21205 USA.

Cell
|February 18, 2014
PubMed
まとめ
この要約は機械生成です。

研究者らは,超高速な細胞サイクルを示す新しい細胞タイプを発見した. この細胞,この細胞.

さらに関連する動画

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

8.6K
A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

1.9K

関連する実験動画

Last Updated: May 3, 2026

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
09:51

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

Published on: April 10, 2026

90
Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

8.6K
A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

1.9K

科学分野:

  • 細胞生物学 細胞生物学
  • 発達生物学 発達生物学とは
  • エピジェネティクス エピジェネティクス

背景:

  • 遺伝子操作なしに非ストキャスティックな細胞再プログラミングは,依然として重要な課題です.
  • 迅速かつ同期的な細胞運命を決定するメカニズムを理解することは極めて重要です.

研究 の 目的:

  • 非遺伝的,急速な再プログラムを行うことができる細胞タイプを特定し,特徴づけること.
  • 超高速な細胞サイクルを持つ細胞の性質を調査する.

主な方法:

  • 細胞サイクル分析 細胞サイクル分析
  • 高解像度イメージング
  • プロジェニー分析 子孫の分析

主要な成果:

  • 超高速細胞サイクルによって定義された細胞の識別.
  • この細胞の子孫が同期的かつ迅速な方法で再プログラムできることを示す.
  • 独特の細胞サイクルダイナミクスの特徴.

結論:

  • 独特の再プログラム特性を持つ新しい細胞タイプが特定されました.
  • 超高速な細胞周期は,観測された同期的かつ急速な再プログラミングの鍵です.
  • この発見は,細胞の運命決定を理解するための新しい道を開きます.