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Updated: May 3, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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in vivoでの再プログラムが早めに終了すると,エピジェネティックの調節が変化した結果,がんが発症する

Kotaro Ohnishi1, Katsunori Semi2, Takuya Yamamoto2

  • 1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Cell
|February 18, 2014
PubMed
まとめ

再プログラム因子の一時的な発現は,体内では腫瘍を誘発する可能性があります. これらの腫瘍は,表遺伝的変化によって引き起こされ,特定の癌に似ているが,遺伝的に不可逆的ではないので,幹細胞の再プログラムと癌の発症との関連が示唆される.

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