下肢表面性血栓炎の治療について
Marcello Di Nisio1, Saskia Middeldorp2
1Department of Medical, Oral, and Biotechnological Sciences, Università "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy2Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
JAMA
|February 20, 2014
まとめ
ファンダパリヌックスは,下肢表面性血栓炎の患者における症状性静脈性血栓栓塞栓 (VTE) と表面性静脈性血栓拡張を効果的に軽減します. 低分子量ヘパリンなどの他の治療法も,延長と再発を防ぐために有望であることが示されています.
科学分野:
- 血管医学 血管医学とは
- トロンボシス研究研究
- 薬理学 薬理学とは
背景:
- 下肢の表面性血栓炎は一般的な症状です.
- 静脈血栓塞栓性イベント (VTE) と延長などの合併症を最小限に抑える治療法を特定することは極めて重要です.
研究 の 目的:
- 下肢表面性血栓炎の治療法を評価する.
- 静脈動脈栓塞症,大出血,表面静脈血栓拡張症のより低い割合との関連を決定する.
主な方法:
- ランダム化制御試験の体系的レビューとメタ解析.
- プラセボに対する様々な抗凝固剤および抗炎症剤の比較.
主要な成果:
- ファンダパリヌックス (45日間毎日2.5mg) は,プラセボと比較して,症状のあるVTE,表面性静脈血栓拡張,および重発を大きく出血を増加させずに大幅に軽減しました.
- 低分子量ヘパリンおよび非ステロイド性抗炎症薬は,延長/再発の減少と関連していたが,VTEデータは決定的ではなかった.
結論:
- フォンダパリヌックスは,下肢表面性血栓炎の有望な治療法であり,VTE予防と局所拡張に利点があります.
- この状態におけるVTEの予防におけるLMWHとNSAIDの役割を明確にするために,さらなる研究が必要である.
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