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Atg16l1のクローン病変体は,カスパース3による分解を強化する

Aditya Murthy1, Yun Li1, Ivan Peng1

  • 1Department of Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

Nature
|February 21, 2014
PubMed
まとめ

クローン病の一般的なリスク遺伝子変種 (ATG16L1 T300A) は,カスパース-3分裂に対してより敏感である. これは,オートファギーの減少と病原体のクリアランスの低下につながり,クローン病の発症に寄与します.

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