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Updated: May 2, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Published on: June 27, 2020

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C11orf95-RELA融合は,エペンジモーマにおける腫瘍性NF-κBシグナル伝達を駆動する

Matthew Parker1, Kumarasamypet M Mohankumar2, Chandanamali Punchihewa3

  • 11] St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA [2] Department of Computational Biology and Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA [3].

Nature
|February 21, 2014
PubMed
まとめ

研究者らは,ほとんどのサプリテントリアル表膜腫において,C11orf95-RELAという新しい遺伝子融合を発見した. この融合は核因子-κB (NF-κB) 信号伝達を活性化し,腫瘍形成を促し,潜在的な治療標的を提供します.

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