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Updated: May 2, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
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タンパク質キナーゼRIPK3の活動は,細胞が死滅またはアポトーシスによって死滅するかどうかを決定する

Kim Newton1, Debra L Dugger, Katherine E Wickliffe

  • 1Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Science (New York, N.Y.)
|February 22, 2014
PubMed
まとめ

受容体相互作用タンパク質キナーゼ3 (RIPK3) キナーゼの活性性は,死滅に不可欠である. 不活性なRIPK3は予期せぬアポトーシスを誘発し,不活性なRIPK1はネクロプトーシスを阻害するが,他の細胞シグナル伝達経路が機能することを許した.

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