成人の人間の脳のストライアトムのニューロゲネシス
Aurélie Ernst1, Kanar Alkass2, Samuel Bernard3
1Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
Cell
|February 25, 2014
まとめ
成人ヒトは,ストライアタムに新しいニューロン統合を示し,この発見は組織学および炭素14年代測定によって支持されています. このニューロゲネシスは内ニューロンに特異的であり,ハンチントン病で影響を受ける.
科学分野:
- 神経科学は神経科学である.
- 人間の神経生物学
背景:
- 哺乳類の脳は,ヒポカンプスと嗅覚球で生涯にわたる神経生成を典型的に表している.
- ニューロブラストは,成人期に生まれたニューロンの前駆体であり,側室壁で生成されます.
研究 の 目的:
- ヒトのストライアタムにおける成人のニューロゲネシスを調査するために.
- 生成されるニューロンの種類と,神経疾患におけるそれらの潜在的な役割を決定する.
主な方法:
- 脳組織のヒスト学的分析.
- ニューロンの年齢を測定するための炭素14年代測定.
主要な成果:
- 新しいニューロンは,既知の神経原性ニッチに隣接する成人ヒトのストライアタムに統合されます.
- ストライアタム内のニューロン周回は,主に内ニューロンで観察されます.
- 産後生成されたストライタルニューロンは,ハンティントン病の患者で好ましい枯渇を示します.
結論:
- 成人の人間の脳は,ストライアトゥームで神経生成のユニークなパターンを示しています.
- ストレイタル神経生成,特に内部神経細胞は,ハンティントン病の病理生理学に関与している可能性があります.
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