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人間のRNase Lの構造は,IFN応答における調節されたRNAの分解の基礎を明らかにする

Yuchen Han1, Jesse Donovan, Sneha Rath

  • 1Department of Molecular Biology, Princeton University, 216 Schultz Laboratory, Princeton, NJ 08540, USA.

Science (New York, N.Y.)
|March 1, 2014
PubMed
まとめ

I型インターフェロンは,RNAを分割する酵素であるRNase Lを活性化させます. 構造研究は,RNase Lが特定のRNA配列を認識し,カットするためにダイマーを形成し,抗ウイルス防御に不可欠であることを明らかにしています.

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