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Updated: May 2, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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チオエステラーゼによるCis-ダブルボンド形成と,FR901464生物合成におけるケトシンタゼによる転移

Hai-Yan He1, Man-Cheng Tang, Feng Zhang

  • 1State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.

Journal of the American Chemical Society
|March 13, 2014
PubMed
まとめ

この研究は,FR901464生物合成におけるポリケチド合成酵素 (PKS) ドメインの新たな機能を明らかにしています. ティオエステラーゼドメインはシス・ダブル・ボンドを形成し,変異したケトシンタゼドメインは中間物質を転送し,PKSメカニズムに関する新しい洞察を提供します.

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