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Complement System01:27

Complement System

10.6K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.6K
Antibody Actions01:26

Antibody Actions

3.9K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
3.9K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
Humoral Immune Responses01:36

Humoral Immune Responses

66.2K
Overview
66.2K
Antibody Structure01:10

Antibody Structure

51.8K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
51.8K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K

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関連する実験動画

Updated: May 2, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

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コンプリメントは,細胞表面に組み立てられたIgGヘクサマーによって活性化されます.

Christoph A Diebolder1, Frank J Beurskens, Rob N de Jong

  • 1Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, 3584 CH Utrecht, Netherlands.

Science (New York, N.Y.)
|March 15, 2014
PubMed
まとめ
この要約は機械生成です。

抗体Fcの相互作用により,補完体を活性化するヘクサマーが形成されます. この発見は,抗体媒介補充活性化を理解し,抗体治療法を改善するためにモデルを提供します.

さらに関連する動画

Depletion of Specific Cell Populations by Complement Depletion
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Depletion of Specific Cell Populations by Complement Depletion

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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

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関連する実験動画

Last Updated: May 2, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

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Depletion of Specific Cell Populations by Complement Depletion
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科学分野:

  • 免疫学 免疫学とは
  • 分子生物学は分子生物学である.
  • バイオケミストリー バイオケミストリー

背景:

  • 抗体による補足体の活性化は,免疫と疾患にとって極めて重要ですが,そのメカニズムは不明です.
  • 抗体-Fc相互作用を理解することは,補完カスケード開始の解明の鍵です.

研究 の 目的:

  • 免疫グロブリンG (IgG) 抗体による補完体活性化のメカニズムを調査する.
  • 補完カスケードの開始におけるFcセグメント相互作用の役割を調査する.
  • 抗体媒介補完活性化および治療設計のためのモデルを開発する.

主な方法:

  • 免疫グロブリンG (IgG) 抗体のFcセグメント間の非共性相互作用を研究した.
  • 細胞に抗原が結合すると,順序付けられた抗体ヘクサマーの形成が観察されました.
  • これらのヘクサマーによるC1 (第1補完成分) の徴募と活性化を研究した.
  • 操作されたFcセグメントの相互作用は,ヒトの4つのIgGサブクラスすべてに及ぶ.

主要な成果:

  • IgG Fcセグメントの間の特定の非共性相互作用は,抗原結合後のオーダーヘクサマーの形成を誘導する.
  • これらの抗体ヘクサマーがC1を効果的に募集し,活性化させ,補完カスケードを開始します.
  • Fcセグメントの相互作用は,ブロック,再構成,強化を含む補完体の活性化を制御するために調節することができます.
  • これらの発見は,4つのヒトIgGサブクラスすべてに適用され,一般的なメカニズムを示しています.

結論:

  • Fcセグメント媒介ヘクサマー形成による抗体媒介補完体活性化のための新しいモデルが提案されています.
  • このメカニズムは,抗体が補完カスケードをどのように誘発するかを理解するための枠組みを提供します.
  • この発見により,抗体ベースの治療法を合理的に設計し,さまざまな用途で有効性を高めることができます.