プリオンのようなポリメリゼーションは,抗ウイルス免疫防御における信号伝導と炎症体活性化の基礎となっている

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Updated: May 2, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

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Xin Cai1, Jueqi Chen1, Hui Xu2

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|March 18, 2014
PubMed
まとめ

免疫センサーRIG-IとNLRP3は,信号伝達のためにプリオン型のタンパク質ポリメリゼーションを使用しています. CARDとPYRINドメインを含むこの保存されたメカニズムは,先天的免疫と炎症反応に不可欠です.

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