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Updated: Jun 28, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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内皮細胞特異性肝キナーゼB1の欠失は,内皮機能不全と高血圧を vivo でマウスで引き起こします

Wencheng Zhang1, Qilong Wang, Yue Wu

  • 1Section of Molecular Medicine, Department of Medicine (W.Z., Q.W., Y.W., C.M., Z.L., X.D., Q.W., M.-H.Z.) and Department of Biochemistry and Molecular Biology (Z.L., M.-H.Z.), University of Oklahoma Health Sciences Center, Oklahoma City; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, China (Y.W., W.L., Z.-Y.Y., M.-H.Z.); and Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China (M.-H.Z.).

Circulation
|March 19, 2014
PubMed
まとめ

内皮 肝臓キナーゼB1 (LKB1) 喪失は,カベオリン-1を増加させることで高血圧と血管機能障害を引き起こす. AMPキナーゼの活性を回復すると,これらの効果は正常化する.

キーワード:
AMPで活性化されたタンパク質キナーゼ.キャベオリン1 キャベオリン1高血圧,高血圧を患っている.オキシド窒素合成酵素III型

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