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Updated: May 2, 2026

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

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抗生物質,パネキシンチャネル,アポトーシスの間の予期せぬ関連

Ivan K H Poon1, Yu-Hsin Chiu2, Allison J Armstrong3

  • 11] The Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA [2] Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA [3] Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA [4] La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.

Nature
|March 21, 2014
PubMed
まとめ

抗生物質のトラバフロクサシンは,アポトーシス中の細胞分解に不可欠なパンネキシン1 (PANX1) チャンネルを阻害する. この発見は,抗生物質と細胞の完全性を結びつけ,新しい抗菌薬の開発を導くかもしれない.

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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