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Updated: May 2, 2026

Measurement of Oxygen Consumption Rate in Acute Striatal Slices from Adult Mice
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PINK1機能喪失変異は,NdufA10ユビキノン解離によるミトコンドリア複合体I活性に影響する

Vanessa A Morais1, Dominik Haddad, Katleen Craessaerts

  • 1VIB Center for the Biology of Disease, 3000 Leuven, Belgium.

Science (New York, N.Y.)
|March 22, 2014
PubMed
まとめ

パーキンソン病のモデルにおけるミトコンドリア複合体I活性の喪失は,NdufA10セリン-250のリン酸化が低下しているとの関連がある. このリン酸化を復元すると,ミトコンドリア機能とシナプス欠陥が回復し,PINK1に関連したパーキンソン病の重要な経路を示唆します.

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