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Updated: May 1, 2026

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ガン細胞のグルコース制限とビグアニドに対する敏感性のメタボリック決定因子

Kıvanç Birsoy1, Richard Possemato1, Franziska K Lorbeer2

  • 11] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA [4] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [5].

Nature
|March 28, 2014
PubMed
まとめ

癌細胞は,ミトコンドリアの酸化リン酸化 (OXPHOS) を上調することで,低グルコースに適応する. このプロセスの欠陥は,突然変異またはグルコース使用の障害によるもので,OXPHOSを阻害する薬に対する感受性を予測します.

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