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Updated: May 1, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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メラノーマにおけるBRAF (V600E) 抑制に対する可逆的および適応的耐性

Chong Sun1, Liqin Wang1, Sidong Huang2

  • 11] Division of Molecular Carcinogenesis, Cancer Systems Biology Centre and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands [2].

Nature
|March 28, 2014
PubMed
まとめ

BRAF/MEK阻害剤に対するメラノーマ耐性は,SOX10の損失から生じ,EGFRを増加させる可能性があります. これは薬剤耐性を説明し,EGFR陽性患者が薬物休暇と再治療から利益を得ることを示唆しています.

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A Melanoma Patient-Derived Xenograft Model07:07

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