母親のレチノイドは,第3型先天性リンパ性細胞を制御し,子孫の免疫を設定します

Serge A van de Pavert¹, Manuela Ferreira², Rita G Domingues³

¹1] Department of Molecular Cell Biology and Immunology, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands [2] Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands. [3].

Nature

|March 28, 2014

まとめ

母親の食事は胎児の免疫発達に影響する. 子宮内でのレチノ酸シグナル伝達は免疫細胞の成熟を制御し,成人の免疫能力とリンパ性臓器のサイズに影響を与えます.

科学分野:

免疫学免疫学とは
発達生物学発達生物学について
栄養科学とは,栄養科学である.

背景:

成人の健康に対する胎児の栄養の影響は知られているが,免疫系の発達への影響は不明である.
二次リンパ性臓器は,胚形成中に形成され,免疫反応に不可欠です.
3型先天性リンパ性細胞 (ILC3),特にリンパ性組織誘発細胞 (LTi) は,リンパ性臓器生成に不可欠です.

研究の目的:

胎児の免疫システム発達における母親の食事とレチノ酸 (RA) 信号伝達の役割を調査する.
母親の栄養が子孫の免疫に影響を与える分子メカニズムを解明する.
子宮内免疫プログラムが成人免疫能力にどのように影響するかを判断する.

主な方法:

胎児のILC3の発達と胚性リンパ性臓器の分化を分析するためにマウスモデルを研究した.
母親のレチノイド摂取量と胎児のRAシグナリングがLTi細胞成熟に及ぼす影響を調査した.
転写因子RORγtとRA受容体を含む調節経路を特定するために遺伝子発現分析を使用しました.

主要な成果:

胎児のILC3は,胚形成中に細胞自律のレチノ酸 (RA) 信号伝達によって調節されます.
母親のレチノイド摂取と胎児のRAシグナル伝達は,LTi細胞の分化と成熟を制御する.
RAシグナリングはRORγtの上流で作用し,RA受容体は直接Rorgtの位置を調節する.
母親の食事レチノイドは,第二リンパ性臓器のサイズと,成人の子孫の免疫応答の効率に影響を与えます.

結論:

母親の栄養,特にレチノイドの摂取は,胎児の免疫発達をプログラムするのに非常に重要です.
子宮内でのレチノ酸シグナル伝達は,リンパ性臓器形成を制御することによって,成人の子孫の免疫能力を確立します.
この研究は,母親の栄養素と,感染抵抗に不可欠な免疫構造の発達との間の分子関連性を明らかにしています.

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