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Updated: May 1, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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アクトキナーゼのカルボキシル末端のリン酸化により,細胞周期調節された活性化

Pengda Liu1, Michael Begley2, Wojciech Michowski3

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature
|March 28, 2014
PubMed
まとめ

Akt (タンパク質キナーゼB) アクティベーションは,さらにS477/T479.9での細胞サイクル依存のリン酸化によって調節されます. この発見は,細胞サイクル進行を癌におけるAkt過活性化と関連付け,細胞増殖と生存に影響を与える.

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