,

S L Diamond1, S G Eskin, L V McIntire

  • 1Rice University, Biomedical Engineering Laboratory, Houston, TX 77251.

Science (New York, N.Y.)
|March 17, 1989
PubMed
まとめ

動脈壁切断ストレスは,内皮細胞による組織プラズミノゲン活性化剤 (tPA) の分泌を著しく増加させます. 静脈切断ストレスおよびすべてのレベルのプラズミノゲン活性化阻害剤1型 (PAI-1) の分泌は影響を受けませんでした.

関連する概念動画

Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...