Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Stem Cell Culture01:17

Stem Cell Culture

4.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
4.5K
Forced Transdifferentiation01:28

Forced Transdifferentiation

1.5K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
1.5K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

3.4K
3.4K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

22.9K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.9K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.8K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Ruptoblasts: Explosive cytotoxicity from an ancient lineage.

Trends in cell biology·2026
Same author

Effect of a Clinical Decision Support System on Team-Based Clinical Quiz Performance Among Japanese Medical Students: A Pre-Post Pilot Study.

Journal of general and family medicine·2026
Same author

Protocol for purifying and sequencing cell subpopulations based on RNA FISH signal in planaria.

STAR protocols·2026
Same author

Syrah: a pipeline to maximize spatial transcriptomics data output.

G3 (Bethesda, Md.)·2026
Same author

eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation.

Cell stem cell·2026
Same author

Temporal AI model predicts drivers of cell state trajectories across human aging.

bioRxiv : the preprint server for biology·2026

関連する実験動画

Updated: May 1, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

11.7K

差別化の再考:幹細胞,再生,そして可塑性

Alejandro Sánchez Alvarado1, Shinya Yamanaka2

  • 1Stowers Institute for Medical Research and Howard Hughes Medical Institute, Kansas City, MO 64110, USA.

Cell
|April 1, 2014
PubMed
まとめ

多細胞生命にとって極めて重要な細胞の分化が再検討されている. 新しい発見は,幹細胞と分化細胞の長年にわたる概念に挑戦し,研究アプローチの再評価を促しています.

科学分野:

  • 発達生物学 発達生物学とは
  • 細胞生物学 細胞生物学
  • 幹細胞の研究について

背景:

  • 細胞の微分化は,多細胞生物の発達,成長,繁殖,長寿に不可欠である.
  • 細胞の微分化の調節は,40年以上にわたって重要な研究分野となっています.
  • 幹細胞 (天然および誘導) に関する最近の研究は,確立された定義の再評価を促しています.

研究 の 目的:

  • 最近の発見が,細胞の微分化の伝統的な概念にどのように挑戦しているかを探求する.
  • 細胞生物学における実験システムとパラダイムの再評価の必要性を強調する.

主な方法:

  • 植物と動物の細胞の分化に関する最近の発見のレビュー.
  • 幹細胞研究における新しい実験操作の分析.
  • 確立された生物学的パラダイムの概念的再評価.

主要な成果:

  • 幹細胞と分化細胞の確立された概念は,新しい発見によって侵食されています.
  • 新しい実験的アプローチは,細胞の運命決定の複雑さを明らかにしています.
  • 既存の研究パラダイムには,大幅な改定が必要になる可能性があります.

さらに関連する動画

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

9.2K
Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells
07:51

Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells

Published on: July 18, 2017

8.4K

関連する実験動画

Last Updated: May 1, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

11.7K
Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

9.2K
Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells
07:51

Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells

Published on: July 18, 2017

8.4K

結論:

  • 細胞の分化の研究は,理解の新たな段階に入っています.
  • 将来の進歩のために,実験システムの批判的な再評価が必要である.
  • 細胞分化研究を進めるには,学際的なアプローチが不可欠です.