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Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
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DNAにおけるグアニン基のカチオンの水分化のメカニズム的な側面

Yekaterina Rokhlenko1, Jean Cadet, Nicholas E Geacintov

  • 1Chemistry Department, New York University , 31 Washington Place, New York, New York 10003-5180, United States.

Journal of the American Chemical Society
|April 3, 2014
PubMed
まとめ

DNAの二次構造は,グアニン基幹のカチオン水分化に影響する. 二重鎖のDNAは,単一鎖のDNAとは異なり,陽子共有メカニズムによって8オキシ-7,8ジヒドログアニン (8-オキシG) の形成を促進する.

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