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Updated: May 1, 2026

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
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定量プロテオミクスは,NCOA4をフェリチノファギーを媒介する貨物受容体として識別する

Joseph D Mancias1, Xiaoxu Wang2, Steven P Gygi3

  • 11] Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA [4] Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature
|April 4, 2014
PubMed
まとめ

研究者らは,核受容体共活性化剤4 (NCOA4) が,特定のタイプのオートファギーのフェリチノファギーの選択的受容体として作用することを発見した. このプロセスは,細胞内の鉄のレベルを調節するために不可欠です.

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