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MTH1の阻害は,dNTPプールの衛生状態を防ぐことによって癌を根絶する

Helge Gad1, Tobias Koolmeister1, Ann-Sofie Jemth1

  • 11] Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden [2].

Nature
|April 4, 2014
PubMed
まとめ

癌細胞はMTH1タンパク質に依存し,酸化した核酸から生じるDNAの損傷を防ぐ. 新しい化合物TH287とTH588でMTH1を阻害すると,がん細胞死亡を引き起こし,MTH1を有望な抗がん標的として検証します.

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