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人間のスキストソミアシス ( schistosomiasis)

Daniel G Colley1, Amaya L Bustinduy2, W Evan Secor3

  • 1Center for Tropical and Emerging Global Disease & Department of Microbiology, University of Georgia, Athens, GA, USA.

Lancet (London, England)
|April 5, 2014
PubMed
まとめ

スキストソミアシス (Schistosomiasis) は,数百万人に感染している寄生虫の感染であり,深刻な健康問題を引き起こします. 現在,プラジクアンテルによる治療は症状を抑えるが,より良い診断と統合管理は,病気の排除に不可欠である.

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科学分野:

  • 医学寄生虫学 医学寄生虫学
  • トロピカル・メディシン (熱帯医学)
  • 公衆衛生は公衆衛生である.

背景:

  • スキストソミアシス (ビルハルジア) は,Schistosoma flukesによって引き起こされる一般的な寄生虫性疾患で,世界中で推定2億3000万人が感染しています.
  • 大人のワームは人の血管に宿り,免疫系を回避し,組織損傷と重度の病変を引き起こす卵を放出します.
  • 病理的な影響には,貧血,成長阻害,認知障害,および肝縮症や線維症のような臓器損傷が含まれます.

研究 の 目的:

  • ヒトのスキストソミアシスに関する現在の理解を要約すると.
  • 既存の病気制御戦略の限界を強調する.
  • 病気の撲滅のために,診断の改善と統合管理の必要性を強調する.

主な方法:

  • Schistosoma spp.に関する既存の文献のレビュー そしてヒトのスキストソミアシス.
  • 現在の公衆衛生の介入とその有効性の分析.
  • 病気の制御と撲滅のための課題と将来の方向性を特定する.

主要な成果:

  • スキストosoma感染は,慢性的な炎症と,閉じ込められた卵による重要な臓器損傷につながります.
  • プラジクアンテル (Praziquantel) は,定期的に投与される,罹病率管理のための主要な薬剤です.
  • 現在の予防対策は,除去には不十分であり,高度な診断と包括的な管理が必要である.

結論:

  • ヒトのスキストソミアシスは,様々な病理学的結果を伴う,世界的な健康上の負担を大きくします.
  • 統合失調症の伝播を効果的に排除するには,早期発見のためのより敏感な診断ツールが必要です.
  • 統合された環境と医療戦略は,病気の撲滅を達成し,持続するために不可欠です.