2

Peng-Fei Xu1, Nathalie Houssin, Karine F Ferri-Lagneau

  • 1Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA.

Science (New York, N.Y.)
|April 5, 2014
PubMed
まとめ

骨形態遺伝タンパク質 (BMP) とノダルシグナル伝達の相反するグラデーションは,多能細胞を十分に発達した斑馬魚胚に組織するのに十分である. この発見は,胚の自己組織化のための最小限の条件を in vivo および in vitro で明らかにしています.

関連する概念動画

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
52.8K
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.2K
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
16.3K