妊娠前の低用量アスピリンと妊娠の結果:EAGeRランダム化試験の結果
Enrique F Schisterman1, Robert M Silver2, Laurie L Lesher2
1Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Lancet (London, England)
|April 8, 2014
まとめ
妊娠前の低用量アスピリンは,1~2回の妊娠中絶を経験した女性の生産率を大幅に改善しなかった. しかし,一般的な予防には推奨されていないが,早期の損失を一度だけ経験した人にとっては有望な結果を示した.
科学分野:
- 生殖医学は,生殖器医学である.
- クリニック・トライアル 臨床試験
- 産科は産婦人科です.
背景:
- 妊娠前低用量アスピリンの妊娠結果への影響を評価する.
- 1〜2回の妊娠中絶歴のある女性における有効性を調査する.
研究 の 目的:
- 妊娠前に開始された低用量のアスピリンが,再発性妊娠中絶の女性における生産率を改善するかどうかを判断する.
- 妊娠前の低用量アスピリンの安全性と有効性を評価するために.
主な方法:
- 1228人の女性を対象とした多センター,ランダム化,ダブルブラインド,プラセボ対照試験です.
- 女性は妊娠前,毎日低用量アスピリン (81 mg) またはプラセボと葉酸を投与された.
- 主なアウトカムは,治療する意図によって分析された生産率でした.
主要な成果:
- 低用量アスピリンを投与した全活産率は58%,プラセボを投与した53% (p=0.0984) であった.
- 妊娠20週未満の単発出産の女性では,アスピリン投与で生育率が著しく高かった (62%対53%,p=0.0446).
- アスピリン投与で陰道出血の増加は認められたが,妊娠中絶と関連していない.
結論:
- 妊娠前の低用量アスピリンは,先の妊娠1~2回で妊娠中絶した女性の生児の改善や妊娠中絶の減少と有意に関連しませんでした.
- 妊娠初期に1回の妊娠中絶を経験した女性では,潜在的な利点が観察されました.
- 現在,低用量のアスピリンは,この集団における妊娠中絶の予防に推奨されていません.
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