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銅は,腫瘍性BRAFシグナル伝達と腫瘍発生のために必要である

Donita C Brady1, Matthew S Crowe1, Michelle L Turski1

  • 1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Nature
|April 11, 2014
PubMed
まとめ

銅のケレーション療法では,BRAF (V600E) がんを治療することができます. 銅トランスポーター1 (CTR1) を減少させ,またはMEK1への銅結合を阻害することで,BRAF (V600E) 信号伝達と腫瘍の成長を抑制します.

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