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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
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ニコチナミドN-メチルトランスフェラーゼノックダウンは,食事による肥満から保護します

Daniel Kraus1, Qin Yang1, Dong Kong2

  • 11] Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA [2] [3] Division of Nephrology, Department of Internal Medicine I, Würzburg University Hospital, Oberdürrbacher Straße 6, 97080 Würzburg, Germany (D.K.); Department of Medicine, Physiology and Biophysics, Center for Diabetes Research and Treatment, and Center for Epigenetics and Metabolism, University of California, Irvine, California 92697, USA (Q.Y.); Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, 00290, Helsinki, Finland (E.P.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie Medicine New Brunswick, Dalhousie University, Saint John, New Brunswick E2L4L5, USA (T.C.P.); Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China (F.G.); School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland (L.A.).

Nature
|April 11, 2014
PubMed
まとめ

ニコチナミドN-メチルトランスフェラーゼ (NNMT) は,肥満と2型糖尿病において上位調節される. NNMTを阻害すると,エネルギー消費が増加し,NAD+とポリアミン代謝に影響を与えることで肥満から保護されます.

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