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Updated: Nov 7, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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TCRとアゴニストペプチド-MHCの間のダイナミックキャッチボンドの蓄積は,T細胞のシグナリングを誘発する

Baoyu Liu1, Wei Chen1, Brian D Evavold2

  • 1Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Cell
|April 15, 2014
PubMed
まとめ

T細胞受容体 (TCR) への機械的な力は,適応免疫を決定する. 力はアゴニストのTCR-pMHC結合 (キャッチ結合) を延長し,アゴニスト結合 (スリップ結合) を短縮し,T細胞のシグナル伝達にカルシウム反応を介して影響を及ぼします.

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