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Updated: May 1, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
04:41

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

Published on: July 14, 2010

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アクティビティ依存のp25生成はシナプス可塑性を調節し,Aβ誘発の認知障害を引き起こします

Jinsoo Seo1, Paola Giusti-Rodríguez1, Ying Zhou1

  • 1The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|April 15, 2014
PubMed
まとめ

ニューロンの活動中にp35から生成されるタンパク質p25は,シナプス可塑性や記憶に役割を果たします. マウスにおけるp25の産生を防ぐことで,アルツハイマー病のモデルにおける認知機能が改善された.

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