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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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Caspase-11の活性化には,IFN誘発のGTPasesによる病原体を含む真空の溶解が必要です

Etienne Meunier1, Mathias S Dick2, Roland F Dreier2

  • 1Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

Nature
|April 18, 2014
PubMed
まとめ

グアニラート結合タンパク質は,グラム陰性細菌を検出する非正規の炎症体経路に不可欠です. これらのタンパク質は,バキュール溶解を誘発し,細菌のリポポリサッカリドの検出と,その後のカスパース-11の活性化を可能にします.

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