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Updated: May 1, 2026

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Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
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Listeria monocytogenesはエフェロサイトーシスを利用して,細胞から細胞への拡散を促進します
Mark A Czuczman1, Ramzi Fattouh2, Jorik M van Rijn3
11] Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G0A4, Canada [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S1A8, Canada.
Nature
|April 18, 2014
まとめ
Listeria monocytogenesは,細胞浄化プロセスであるエフェロサイトーシスを利用して,宿主細胞間で広がります. この病原体は,孔を形成する毒素を使用して,フォスファティディルセリン (PS) を含んだ膀を作り,その後,他の細胞に吸収され,感染を助長します.
科学分野:
- 免疫学 免疫学とは
- 微生物学 微生物学とは
- 細胞生物学 細胞生物学
背景:
- エフェロサイトーシスは,死んだ細胞を除去し,組織の健康を維持するために不可欠です.
- 死んでいる細胞のフォスファティディルセリン (PS) に結合する受容体はエフェロサイトーシスを媒介する.
- バクテリアの病原体は,潜在的に宿主細胞のプロセスを自分の利益のためにハイジャックすることができます.
研究 の 目的:
- Listeria monocytogenesが細胞から細胞に拡散するためにエフェロサイトーシスをどのように利用するのかを調査する.
- このプロセスに関与する細菌因子と宿主受容体を特定する.
主な方法:
- 宿主細胞におけるListeria monocytogenes感染を研究した.
- バクテリアの脱出と突起形成におけるリステリオリシンO (LLO) とACTAの役割を分析した.
- PS結合受容体TIM-4の関与を in vitroアッセイとTimd4ノックアウトマウスを使用して調査しました.
主要な成果:
- Listeria monocytogenesはLLOを使用して宿主細胞膜を損傷し,細菌を含む突起を形成します.
- これらの突起は,PSを暴露する膀として放出され,他の細胞によるエフェロサイトーシスを促進します.
- TIM-4はマクロファージによるこれらの水泡の吸収を媒介し,細菌の拡散を促進します.
- L.monocytogenesの成長は,Timd4 (((-/-) のマウスで減少していました.
結論:
- Listeria monocytogenesは,宿主内の拡散のためにエフェロシトーシスを積極的に利用します.
- 病原体の細胞間拡散メカニズムは,LLO誘発の膜損傷とPSを表示する膀を含む.
- PS媒介のエフェロサイトーシスをターゲットにすることは,L. monocytogenesの感染に対する治療戦略である可能性があります.
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