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Updated: May 1, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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アロステリーの集合的な性質

Hesam N Motlagh1, James O Wrabl1, Jing Li1

  • 1Department of Biology and T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Nature
|April 18, 2014
PubMed
まとめ

タンパク質の活性を調節するアロステリー (Allostery) は,ダイナミックで,本質的に乱れたタンパク質を含むことが理解されています. この新しいパラダイムは,生物学的システムにおける情報伝達を説明するために,構成的集合に重点を置いています.

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Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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