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Updated: Mar 29, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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カストレーション耐性前立腺がんにおけるBETブロモドメインタンパク質の治療標的化

Irfan A Asangani1, Vijaya L Dommeti2, Xiaoju Wang1

  • 11] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Nature
|April 25, 2014
PubMed
まとめ

JQ1のようなブロモドメインおよびエクストラトミナル (BET) 阻害剤は,進行前立腺がんの治療に有望であることが示されています. これらの阻害剤はBRD4を標的にし,アンドロゲン受容体のシグナル伝達を妨害し,カストレーション耐性前立腺がんに対する新しいエピジェネティックアプローチを提供します.

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