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関連する概念動画

Somatosensation01:33

Somatosensation

36.9K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.9K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

9.1K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
9.1K
Cells of the Epidermis01:24

Cells of the Epidermis

7.2K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
7.2K
Introduction to Special Senses01:26

Introduction to Special Senses

6.7K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
6.7K
Unrenewable Cells00:50

Unrenewable Cells

2.1K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.1K
Design Example: Resistive Touchscreen01:14

Design Example: Resistive Touchscreen

949
A device engineer plays a crucial role in designing user interfaces for mobile devices. One such interface is the resistive touchscreen, which fundamentally consists of two metallic layers: a flexible upper layer and a rigid lower layer, separated by a narrow gap. The high resistance between these two layers is a key characteristic of this design.
When a user touches the screen, the two layers make contact at a specific point known as the touchpoint. This contact reduces the resistance between...
949

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関連する実験動画

Updated: Apr 30, 2026

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects
07:32

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects

Published on: September 1, 2016

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メルケル細胞は,敏感な話題です.

Qiufu Ma1

  • 1Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 450 Brookline Street, Boston, MA 02115, USA.

Cell
|April 29, 2014
PubMed
まとめ

メルケル細胞は触覚感覚の主要な部位であり,伝導のためにPiezo2イオンチャネルを使用します. また,これらの細胞は,アロディニアにおいて驚くべき役割を果たし,慢性疼痛治療の新たな標的となる.

科学分野:

  • 神経科学は神経科学である.
  • 細胞生物学 細胞生物学
  • 感覚生理学 感覚生理学とは

背景:

  • メルケル細胞-ニューライト複合体が触覚情報を感知し処理するメカニズムは完全に理解されていません.
  • メルケル細胞は,神経末端に関連した特殊な皮膚細胞であり,伝統的に触覚知覚に関与しています.

研究 の 目的:

  • 触覚変換におけるメルケル細胞および関連する分子機構の特定の役割を明らかにする.
  • アロジニア現象におけるメルケル細胞の関与とその潜在的な治療的影響について調査する.

主な方法:

  • 先進的なイメージング技術を使用して,メルケル細胞-ニューライトの相互作用を in vivo で観察しました.
  • メルケル細胞のピエゾ2イオンチャネルの機能を評価するために,遺伝子操作を用いた.
  • 実験モデルで触覚刺激と機械的な痛みに対する行動反応を調査した.

主要な成果:

  • 機械的な触覚刺激を神経信号 (触覚伝導) に初期変換する主要な部位としてメルケル細胞を特定した.
  • ピエゾ2イオンチャネルが,メルケル細胞によって媒介されるこの触覚変換プロセスに不可欠であることを実証した.
  • メルケル細胞は,痛み過敏症の一種であるアロディニアの発生に重要に関与していることが明らかになった.

さらに関連する動画

Merkel Cell Polyomavirus Infection and Detection
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Merkel Cell Polyomavirus Infection and Detection

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Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

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関連する実験動画

Last Updated: Apr 30, 2026

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects
07:32

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects

Published on: September 1, 2016

12.2K
Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

9.6K
Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

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結論:

  • メルケル細胞は,Piezo2が鍵となるメカノセンサとして機能し,タッチの主要なトランスデューサーであると確認されています.
  • メルケル細胞がアロジニアにおける役割を発見したことで,慢性疼痛疾患の治療法を開発するための新しい細胞標的となる.