関連する実験動画

Updated: Apr 30, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

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癌に関連したPTEN変異体は,PTENタンパク質の機能を抑制するために,支配的ネガティブな方法で作用します

Antonella Papa1, Lixin Wan2, Massimo Bonora3

  • 1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Cell
|April 29, 2014
PubMed
まとめ

PTENタンパク質は,その活性を調節するために二重体を形成します. 癌に関連したPTEN変異は,この機能を損なうことになり,腫瘍の感受性の増加と完全なPTEN喪失に似た効果につながります.

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