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Updated: Apr 1, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

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絶対的なタンパク質合成速度を定量化することで,細胞資源の配分を支える原理が明らかになる

Gene-Wei Li1, David Burkhardt2, Carol Gross3

  • 1Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell
|April 29, 2014
PubMed
まとめ

この研究では,E. coliの絶対タンパク質合成率を測定するために,全ゲノムにわたるリボソームプロファイリング方法を導入しています. 発見は,細胞の効率と機能の最適化のためのタンパク質生産の正確な制御を明らかにします.

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