Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

3.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
3.2K
Indirect Motor Pathways01:22

Indirect Motor Pathways

3.4K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
3.4K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

5.0K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
5.0K
Neural Circuits01:25

Neural Circuits

3.0K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.0K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

4.9K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
4.9K
Glial Cells01:04

Glial Cells

75.2K
Overview
75.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Right on cue-Neuronal signals guide myelination in the developing cortex.

Developmental cell·2026
Same author

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport.

bioRxiv : the preprint server for biology·2026
Same author

Enhancing myelination in a high-poxic environment.

Neuron·2026
Same author

Brain-Immune Crosstalk in Mental Illness: The Path to Immunopsychiatry.

Biological psychiatry·2026
Same author

First-in-Human Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Oral Doses of BIIB091, an Oral BTK Inhibitor, in Healthy Adult Participants.

Drug design, development and therapy·2026
Same author

Lung adventitial fibroblasts support type 2 Tregs to shape the response to influenza infection.

bioRxiv : the preprint server for biology·2026

関連する実験動画

Updated: Apr 30, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K

アストロサイトでコードされた位置的シグナルは,センソモーター回路の整合性を維持します.

Anna V Molofsky1, Kevin W Kelley2, Hui-Hsin Tsai3

  • 11] Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA [2] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California 94143, USA [3] Department of Psychiatry, University of California San Francisco, San Francisco, California 94143, USA.

Nature
|April 30, 2014
PubMed
まとめ
この要約は機械生成です。

脊髄における地域特有のアストロサイトは,重要な位置情報を提供する. ベントラアストロサイトで分泌されるセマフォリン3a (Sema3a) は,発達中の運動神経および感覚神経回路組織に不可欠です.

さらに関連する動画

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

8.5K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

8.6K

関連する実験動画

Last Updated: Apr 30, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

8.5K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

8.6K

科学分野:

  • 神経科学は神経科学である.
  • 発達生物学 発達生物学について
  • 細胞生物学 細胞生物学

背景:

  • アストロサイトは,中枢神経系 (CNS) で最も豊富に存在する膠質細胞です.
  • アストロサイトはシナプス形成と神経回路の精製に役割を果たします.
  • 発達中の領域限定アストロサイトの機能的異質性は,ほとんど不明のままである.

研究 の 目的:

  • 産後脊髄アストロサイトにおける機能的異質性を調査する.
  • センソモーター回路組織における地域特有のアストロサイト由来因子の役割を決定する.

主な方法:

  • 産後脊髄アストロサイトにおける地域特有の遺伝子発現の分析.
  • センソモーター回路の発達におけるセマフォリン3a (Sema3a) の役割の調査.
  • セマ3a喪失後のモーターニューロンおよび感覚ニューロン回路組織の評価.

主要な成果:

  • 産後脊髄アストロサイトは,地域特有の遺伝子発現を示す.
  • ベントラアストロサイトから派生したSema3aは,正しい運動ニューロンと感覚ニューロン回路組織に不可欠です.
  • アストロサイトSema3aの喪失は,異常なモーターニューロン軸索誘導,シナプス入力,選択的なモーターニューロン死,子宮外感覚アファレント投影を伴う.

結論:

  • 発達中のアストロサイトは,センサーモーター回路形成に影響を与える安定した位置的シグナルを提供します.
  • 地域的なアストロサイト異質性は,産後神経回路の精製の調整に寄与する.
  • アストロサイトでコードされたセマフォリン3aは,正確なセンソモーター回路を確立する上で重要な要因です.