ゲノム防衛小型のRNAは,エピジェネティックな交配型の遺伝のために抽出されています
Deepankar Pratap Singh1, Baptiste Saudemont2, Gérard Guglielmi3
11] Ecole Normale Supérieure, Institut de Biologie de l'ENS, IBENS; Inserm, U1024; CNRS, UMR 8197 Paris F-75005, France [2] Sorbonne Universités, UPMC Univ., IFD, 4 place Jussieu, 75252 Paris cedex 05, France.
Nature
|May 9, 2014
まとめ
小型RNAは,パラメシウムのDNA配列の削除を誘導し,交配型が世代を超えてどのように遺伝されるかを説明します. このエピジェネティックメカニズムは,本質的な特徴の伝播を保証します.
科学分野:
- エピジェネティクス エピジェネティクス
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
背景:
- パラメシウムでは,転置可能な元素はマクロ核発達の過程で削除されます.
- 分離過程で生成される小さなRNA (scnRNAs) は,これらの欠損を標的とする.
研究 の 目的:
- パラメシウムテトラウレリアの交配型の母性遺伝におけるscnRNA誘導デレーションの役割を調査する.
- パラメシウム種における交配型決定の遺伝的根拠を理解する.
主な方法:
- scnRNAに依存するDNA消去機構の分析.
- パラメシウム種における交配型遺伝子 (mtAとmtB) の比較ゲノミクス.
主要な成果:
- mtAプロモーターのscnRNA誘導切除により,P. tetraureliaの交配型Oが決定される.
- mtB遺伝子のコード配列の削除により,P. septaurelia. の交配型Oが決定される.
- この2つのメカニズムは,scnRNA媒介による遺伝子調節と表遺伝的遺伝を含んでいます.
結論:
- scnRNA経路は,細胞遺伝子を調節し,世代を超えたエピジェネティック遺伝を媒介するために抽出されています.
- パラメシウムの種で独立に進化したメカニズムは,scnRNA誘導の消去の適応性を強調しています.
- この研究は,交配型の母性遺伝という長年の問題を解決している.
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