Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cancer02:18

Cancer

55.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.1K
No description available
3.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.2K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.4K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.4K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Factors Associated With Early Mortality in Patients Treated With Concurrent Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer.

International journal of radiation oncology, biology, physics·2016
Same author

Using Tomoauto: A Protocol for High-throughput Automated Cryo-electron Tomography.

Journal of visualized experiments : JoVE·2016
Same author

MiR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10.

Clinical immunology (Orlando, Fla.)·2016
Same author

Minicells, Back in Fashion.

Journal of bacteriology·2016
Same author

A new variant of rabbit hemorrhagic disease virus G2-like strain isolated in China.

Virus research·2016
Same author

Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine·2016

関連する実験動画

Updated: Mar 28, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

8.1K

内なる火:微生物が腫瘍を炎上させる

Nicola Gagliani1, Bo Hu1, Samuel Huber2

  • 1Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.

Cell
|May 13, 2014
PubMed
まとめ

腸内微生物群と免疫系は腸内バランスを維持する. 不均衡は炎症を引き起こし,腸内腫瘍の発症を促進し,がんの研究と治療のための新しい道を開くことができます.

さらに関連する動画

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

8.9K
A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

11.0K

関連する実験動画

Last Updated: Mar 28, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

8.1K
Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

8.9K
A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

11.0K

科学分野:

  • 免疫学 免疫学とは
  • 微生物学 微生物学とは
  • 腫瘍学 腫瘍学

背景:

  • 腸内免疫系と腸内微生物群は,腸内ホメオスタシスにとって極めて重要な共生関係を維持しています.
  • ディスバイオシス,または微生物群の不均衡は,この関係を破壊し,慢性炎症につながる可能性があります.
  • 慢性炎症は,腸内腫瘍発達の原動力として知られています.

研究 の 目的:

  • 腸内における微生物群と免疫系の相互作用の理解における最近の進歩をレビューする.
  • これらの相互作用が腸がんの生物学にどのように影響するかを探求する.
  • これらの相互作用をがん治療の標的とする治療の可能性について議論する.

主な方法:

  • 腸内微生物群と免疫に関する現在の研究の文献レビュー.
  • 炎症と腫瘍発生における微生物成分の役割を調査する研究の分析.
  • がん研究における新しい方向性を特定するために,発見の合成.

主要な成果:

  • 微生物群と先天的および適応的免疫システムとの間には複雑な相互作用が存在します.
  • 微生物群のディスバイオシスは慢性腸炎症に大きく寄与する.
  • この炎症は,腸内腫瘍の発生と進行に有利な微環境を作り出します.

結論:

  • 微生物群と免疫系の交信を理解することは,がんの生物学を解読するために不可欠です.
  • 腸内微生物群と免疫系をターゲットにすることで,腸がんに対する有望な治療戦略が提供されます.
  • これらの相互作用に関するさらなる研究は,新しいがん治療の道を開くことができます.