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Updated: Apr 30, 2026

A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
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固有のアポトーシス経路は,C. elegansにおけるミトコンドリアのROSに対するプロロングライフ応答を媒介する

Callista Yee1, Wen Yang1, Siegfried Hekimi1

  • 1Department of Biology, McGill University, Montreal, QC H3A 1B1, Canada.

Cell
|May 13, 2014
PubMed
まとめ

ミトコンドリアのROSシグナル伝達は,アポトーシス経路を活性化することによって,C. elegansの寿命を延ばし,細胞死を誘発するのではなく,保護性遺伝子発現を誘発し,ストレス下での生存を促進します.

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